This comprehensive reference for novice students and experienced scientists studying DNA in organisms compares and evaluates the technological choices available in detecting genetic variances in pharmacogenomics. Commonly used technologies such as sequencing, DNA array and chip technologies, mass spectrometry, gel- and chromatography-based technologies, as well as less commonly used methods are described in detail and illustrated with specific examples. Expert advice is presented on technological options to facilitate decisions about the utility and applicability of individual technologies for specific needs.

Genetic Variance Detection - Technologies for Pharmacogenomics is Karl Hecker’s second book about technologies for genetic variance detection. It broadly covers a wide range of technologies currently used for genetic variance detection and constitutes an essential contribution to the field. A reference guide for every molecular biology laboratory. His first book Genetic Variance Detection - Nuts & Bolts of DHPLC in Genomics (ISBN 0966402774) provides comprehensive and in depth coverage of denaturing high-performance liquid chromatography and is an invaluable reference for anyone using or planning to use DHPLC for genetic variance detection.

Norbert Arnold, Professor Dr. rer. nat.
University Hospital Schleswig-Holstein, Kiel, Germany

(Editor) Kartl Hecker, Ph.D. is a Research Scientist with PerkinElmer Corporation.